An overdose of topical Diclofenac Gel is extremely unlikely due to the low systemic absorption of this dosage form. Oral ingestion of topical Diclofenac sodium gel resulting in significant systemic side effects, although not reported to have occurred to date, may be treated as follows: Treatment of overdose: To decrease absorption: Induction of emesis and/ or gastric lavage should be initiated.
Oral administration of activated charcoal may help reduce absorption.
To enhance elimination: Forced diuresis theoretically may increase urinary excretion.
Note: The use of dialysis or hemoperfusion to enhance elimination of highly protein-bound Diclofenac is unproven.
Specific treatment: Symptomatic treatment for potential complications (such as renal failure, seizures, gastrointestinal irritation, and respiratory depression) may be given.
Supportive care: Patients in whom intentional overdose is confirmed or suspected should be referred for psychiatric consultation